Functional binding interaction identified between the axonal CAM L1 and members of the ERM family

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Functional binding interaction identified between the axonal CAM L1 and members of the ERM family

A yeast two-hybrid library was screened using the cytoplasmic domain of the axonal cell adhesion molecule L1 to identify binding partners that may be involved in the regulation of L1 function. The intracellular domain of L1 bound to ezrin, a member of the ezrin, radixin, and moesin (ERM) family of membrane-cytoskeleton linking proteins, at a site overlapping that for AP2, a clathrin adaptor. Bi...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2002

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb.200111076